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US 6,077,543 AGranted
Systems and processes for spray drying hydrophobic drugs with hydrophilic excipients
AssigneeInhale Therapeutic Systems
InventorsMarc S. Gordon, Andrew Clark, Thomas K. Brewer
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Abstract
Methods for preparing dry powders having hydrophobic and hydrophilic components comprise combining solutions of the components and spray drying them simultaneously in a spray dryer. The hydrophilic and hydrophobic component are separately dissolved in separate solvents and directed simultaneously through a nozzle, usually a coaxial nozzle, into the spray dryer. The method provides dry powders having relatively uniform characteristics.
Claims17
A method for preparing a dry powder composition, said method comprising:
- preparing an aqueous solution of a hydrophilic component;
- preparing an organic solution of a hydrophobic component in an organic solvent;
- and
- delivering the aqueous solution containing the hydrophilic component to an atomizer;
- delivering the organic solution containing the hydrophobic solution to the atomizer separately from the aqueous solution containing the hydrophilic solution;
- atomizing the two solutions together in the atomizer to produce droplets containing both solutions;
- spray drying the droplets of the aqueous solution and the organic solution to form dry particles comprising a mixture of the hydrophilic and hydrophobic component.
4 more elements
Dependencies are inferred from the claim text.