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US 6,072,038 AGranted
Conjugates of texaphyrins
AssigneeBoard of Regents, The University of Texas System
InventorsJonathan L. Sessler, Tarak D. Mody, Gregory W. Hemmi
Life of this patent
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Abstract
The invention relates to the field of radiation sensitizers and the use of texaphyrins for radiation sensitization and other conditions for which X-ray radiation has proven to be therapeutic.
Claims17
A texaphyrin-biomolecule conjugate, wherein the texaphyrin is hydroxylated.
A texaphyrin-biomolecule conjugate, wherein the texaphyrin is water-soluble.
A texaphyrin-biomolecule conjugate wherein the texaphyrin is represented by the following structure:
- ##STR7## where, M is a divalent metal cation or a trivalent metal cation;
- R.sub.1 -R.sub.4, R.sub.7 and R.sub.8 are independently hydrogen, hydroxyl, alkyl, aryl, hydroxyalkyl, oxyalkyl, oxyhydroxyalkyl, saccharide, carboxyalkyl, carboxyamidealkyl, a biomolecule, or a couple to a biomolecule;
- where at least one of R.sub.1, R.sub.7 and R.sub.8 is oxyhydroxyalkyl, saccharide, oxyalkyl, carboxyalkyl, carboxyamidealkyl, or hydroxyalkyl having at least one hydroxy substituent, and provided that R.sub.7 is the same as R.sub.8 ;
- R.sub.5, R.sub.6, R.sub.9 and R.sub.10 are hydrogen;
- and
- N is zero, 1 or 2;
- provided that, at least one of R.sub.1 -R.sub.4, R.sub.7 and R.sub.8 is a biomolecule or a couple to a biomolecule.
4 more elements
Dependencies are inferred from the claim text.