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US 6,071,957 AGranted
Irreversible non-steroidal antagonist compound and its use in the treatment of prostate cancer
AssigneeThe University of Tennessee Research Corporation
InventorsDuane D. Miller, Leonid I. Kirkovsky, James T. Dalton, Arnab Mukherjee
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Abstract
The present invention relates to an antiandrogen compound and a method of treating prostate cancer in a patient utilizing the compound. The present invention also relates to a pharmaceutical composition which includes the compound.
Claims15
A method for treating prostate cancer in a patient comprising:
- administering to the patient an effective amount of a compound having the formula:
- ##STR42## where Z is NCS or CN,
- R is NH.sub.2, NCS, N.sub.3 or NHCOCH.sub.2 Y,
- X is S or SO.sub.2, and
- Y is a halogen or
- where
- Z is NCS,
- R is F, and
- X is S or SO.sub.2 ;
- and
- wherein the compound binds irreversibly to an androgen receptor of the patient.
8 more elements
A compound having the formula:
- ##STR43## where Z is NCS or CN,
- R is NH.sub.2, NCS, N.sub.3 or NHCOCH.sub.2 Y,
- X is S or SO.sub.2, and
- Y is a halogen or
- where
- Z is NCS,
- R is F, and
- X is S or SO.sub.2 ;
- and
- wherein the compound binds irreversibly to an androgen receptor of a mammal.
7 more elements
A pharmaceutical composition comprising:
- a pharmaceutically acceptable carrier and a compound having the formula ##STR44## where Z is NCS or CN,
- R is NH.sub.2, NCS, N.sub.3 or NHCOCH.sub.2 Y,
- X is S or SO.sub.2, and
- Y is a halogen or
- where
- Z is NCS,
- R is F, and
- X is S or SO.sub.2.
5 more elements
Dependencies are inferred from the claim text.