Screening method for therapeutic agents against Alzheimer's disease
AssigneeMitsubishi Chemical Corporation
InventorsAkihiko Takashima, Toshimitsu Hoshino, Kazutomo Imahori, Ken-ichi Saito, Akiko Shiratsuchi, Showbu Sato
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Abstract
A preventive or therapeutic agent for Alzheimer's disease which comprises a substance exhibiting an inhibitory action to tau-protein kinase I as an effective component is provided. A pharmaceutical composition comprising said agent and a method of inhibiting neuronal cell death in the brain are also provided.
Claims18
A method for screening an agent useful for prevention or therapy of Alzheimer's disease comprising the steps of:
- incubating an agent which exhibits an inhibitory action on tau-protein kinase I with amyloid beta-protein and nerve cells, and assessing the ability of said agent to inhibit the death of said nerve cells to determine whether said agent is effective as a preventive or therapeutic agent for Alzheimer's disease.
A method for screening a plurality of test compounds to identify a test compound useful as an agent for prevention or therapy of Alzheimer's disease, comprising the steps of:
- incubating each of the test compounds which exhibits an inhibitory action on tau-protein kinase I with amyloid beta-protein and nerve cells, and
- identifying the test compound which inhibits death of the nerve cells, thereby to identify a test compound useful as an agent for prevention or therapy of Alzheimer's disease.
A method for identifying a test compound useful as an agent for prevention or therapy of Alzheimer's disease, comprising the steps of:
- incubating a test compound which exhibits an inhibitory action on tau-protein kinase I with amyloid beta-protein and nerve cells, and
- identifying the test compound which inhibits death of the nerve cells, thereby to identify a test compound useful as an agent for prevention or therapy of Alzheimer's disease.
Dependencies are inferred from the claim text.