Methods for treating thrombotic disorders
AssigneeEli Lilly and Company
InventorsBrian William Grinnell, Joseph Anthony Jakubowski
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Abstract
The present invention provides a method of treatment for patients with a variety of thrombotic disorders including, but not limited to, stroke, venous thrombosis, myocardial infarction, unstable angina, abrupt closure following angioplasty or stent placement, and thrombosis as a result of peripheral vascular surgery. Said treatment is a combination therapy with human aPC and antiplatelet agents including, but not limited to, aspirin (ASA), clopidogrel, ReoPro.RTM. (abciximab), dipyridamole, ticlopidine and IIb/IIIa receptor antagonists. The synergy will result in the ability to reduce the dosages of the agents used in the combination therapy.
Claims20
A method of treating a thrombotic disorder in a patient in need thereof, which comprises, administering to said patient a pharmaceutically effective amount of a combination of activated protein C and an antiplatelet agent.
A method of treating a thrombotic disorder in a patient in need thereof, which comprises administering to said patient a pharmaceutically effective amount of an antiplatelet agent and activated protein C such that an activated protein C plasma level of 10 ng/ml to less than 100 ng/ml is achieved.
Dependencies are inferred from the claim text.