Compositions for treatment of diabetic complications
AssigneeScotia Holdings PLC
InventorsDavid Frederick Horrobin, Mary Cotter, Norman Cameron
Life of this patent
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Abstract
Use of 6-desaturated n-6 fatty acids, especially gammalinolenic acid (GLA), dihomogammalinolenic acid (DGLA) or arachidonic acid (AA), together with a pharmaceutically acceptable material reducing intracellular levels of sorbitol in the body, particularly an aldose reductase inhibitor, in the treatment of (including prophylactic treatment), and in the preparation of medicaments for the treatment of (including prophylactic treatment), the long-term complications of diabetes mellitus. Pharmaceutical compositions of said materials. The ascorbate esters of 6-desaturated n-6 fatty acids (other than GLA or DGLA) per se.
Claims11
A pharmaceutical composition comprising a 6-desaturated n-6 fatty acid together with a material reducing intracellular levels of sorbitol in the body, said material being a material other than ascorbic acid or ascorbate in any form, wherein the combination when administered to treat long term complications of diabetes mellitus provides a synergistic reduction of intracellular levels of sorbitol in the body.
A method of treating long term complications of diabetes mellitus comprising administering to a patient in need thereof an effective amount of a 6-desaturated n-6 fatty acid together with a pharmaceutically acceptable material reducing intracellular levels of sorbitol in the body, with the proviso that if said material is ascorbate then the ascorbate is present in combined form with said 6-desaturated n-6 fatty acid as an ascorbyl-essential fatty acid (EFA) ester, wherein in said treatment the combination provides a synergistic reduction of intracellular levels of sorbitol in the body.
Dependencies are inferred from the claim text.