Use of antioxidant agents to treat cholestatic liver disease
AssigneeUniversity Technology Corporation
InventorRonald J. Sokol
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Abstract
The present invention relates to formulations and methods for preventing and treating liver injury and fibrosis in cholestasis. This is accomplished by the administration of a composition which includes selected antioxidants.
Claims8
A pharmaceutically active antioxidant containing composition consisting essentially of a formulation to deliver to a patient Vitamin E in an amount between about 50 to about 100 IU/kg/day, beta carotene in an amount of between about 0.5 to 5.0 mg/kg/day, and selenium in an amount of about 1.0 to 5.0 micrograms/kg/day.
A method of preventing and treating liver injury and fibrosis in cholestasis in mammalian organisms, said method comprising the step of administering a formulation including the compounds Vitamin E, beta carotene and selenium, each of said compounds of said formulation being present in an amount effective to treat cholestasis, to a mammalian organism in need of such treatment.
A pharmaceutically active composition comprising a formulation to deliver to a patient Vitamin E in an amount between about 50 to about 100 IU/kg/day, beta carotene in an amount of between about 0.5 to 5.0 mg/kg/day, and selenium in an amount of about 1.0 to 5.0 .mu.g/kg/day.
Dependencies are inferred from the claim text.