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AssigneeBoard of Regents, The University of Texas System
InventorsJonathan L. Sessler, Tarak D. Mody, Gregory W. Hemmi
Estimating the term…
Texaphyrins are provided for use as radiation sensitizers. Advantageous properties of texaphyrins for use as a radiation sensitizer include: i) a low redox potential which allows radiation-induced hydrated electrons to flow to texaphyrin rather than neutralizing hydroxyl radicals, allowing hydroxyl radicals to cause cellular damage, ii) a relatively stable texaphyrin radical that reacts readily to covalently modify neighboring molecules causing further cellular damage, iii) intrinsic biolocalization, and iv) indifference to the presence or absence of O.sub.2. These properties allow texaphyrins to be particularly effective for treating the hypoxic areas of solid neoplasms. Methods of treatment for an individual having a neoplasm or atheroma include the use of a texaphyrin as a radiation sensitizer and as an agent for photodynamic tumor therapy, or the use of a texaphyrin for internal and for external ionizing radiation. Novel texaphyrins are provided.
A pharmaceutical composition comprising an effective amount of a hydroxy substituted texaphyrin and a pharmaceutically acceptable carrier.
A pharmaceutical composition comprising an effective amount of a texaphyrin and a pharmaceutically acceptable carrier, wherein the texaphyrin is represented by the following structure:
A pharmaceutical composition comprising an effective amount of a texaphyrin and a pharmaceutically acceptable carrier, wherein the texaphyrin has the following structure:
Dependencies are inferred from the claim text.