Elastin derived composition and method of using same
AssigneeMrs, LLC
InventorsLawrence B. Sandberg, Philip J. Roos, Thomas F. Mitts
Life of this patent
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Abstract
The present invention is directed to a formulation or composition which is used to enhance the softness, elastin, or appearance of tissue by increasing the endogenous elastin production. Specifically, the present invention is directed to a composition formulated from the products of thermolysin digestion which are filtered through a 10,000 molecular weight cutoff device, which may be dried to have a formulation which contains 90% or greater of peptides having a molecular weight lower than 10,000 Da. This formulation is preferably applied to human skin in a cosmetic or therapeutic formulation and results in enhanced elasticity of the skin.
Claims46
A composition useful in treating mammalian tissue, said composition being comprised of a peptide selected from the group consisting of of SEQ ID NO:
- 17 (Valine-Valine-Proline-Glutamine), SEQ ID NO:
- 18 (Valine-Alanine-Alanine-Arginine-Proline-Glycine), SEQ ID NO:
- 19 (Leucine-Glycine-Alanine-Glycine-Glycine-Alanine-Glycine), and SEQ ID NO:
- 23 (Valine-Glycine-Valine-Hydroxyproline-Glycine).
A composition useful in improving tissue turgor, said composition being comprised of a peptide selected from the group consisting of SEQ ID NO:
- 17 (Valine-Valine-Proline-Glutamine), SEQ ID NO:
- 18 (Valine-Alanine-Alanine-Arginine-Proline-Glycine), SEQ ID NO:
- 19 (Leucine-Glycine-Alanine-Glycine-Glycine-Alanine-Glycine), and SEQ ID NO:
- 23 (Valine-Glycine-Valine-Hydroxyproline-Glycine).
A method of enhancing tissue elasticity, said method being comprised of administering a therapeutically effective concentration of a peptide selected from the group consisting of SEQ ID NO:
- 17 (Valine-Valine-Proline-Glutamine), SEQ ID NO:
- 18 (Valine-Alanine-Alanine-Arginine-Proline-Glycine), SEQ ID NO:
- 19 (Leucine-Glycine-Alanine-Glycine-Glycine-Alanine-Glycine, and SEQ ID NO:
- 23 (Valine-Glycine-Valine-Hydroxyproline-Glycine).
A pharmaceutical composition comprised of a peptide selected from the group consisting of SEQ ID NO:
- 17 (Valine-Valine-Proline-Glutamine), SEQ ID NO:
- 18 (Valine-Alanine-Alanine-Arginine-Proline-Glycine), SEQ ID NO:
- 19 (Leucine-Glycine-Alanine-Glycine-Glycine-Alanine-Glycine) and SEQ ID NO:
- 23 (Valine-Glycine-Valine-Hydroxyproline-Glycine).
A composition comprised of SEQ ID NO:
- 17 (Valine-Valine-Proline-Glutamine).
A composition comprised of SEQ ID NO:
- 18 (Valine-Alanine-Alanine-Arginine-Proline-Glycine).
A composition comprised of is SEQ ID NO:
- 23 (Valine-Glycine-Valine-Hydroxyproline-Glycine).
A composition comprised of SEQ ID NO:
- 19 (Leucine-Glycine-Alanine-Glycine-Glycine-Alanine-Glycine).
Dependencies are inferred from the claim text.