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US 6,068,987 AGranted
Histone deacetylase as target for antiprotozoal agents
AssigneeMerck & Co., Inc.
InventorsPaula M. Dulski, Robert W. Myers, Anne M. Gurnett, Sandra J. Rattray, Dennis M. Schmatz
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Abstract
Histone deacetylase inhibition provides a target for identifying potential antiprotozoal compounds. Histone deacetylase inhibitors are useful as therapeutic agents against protozoal infections.
Claims2
A method for identifying compounds having antiprotozoal histone deacetylase activity comprising:
- (a) contacting an intact protozoal cell with a test compound or a natural product extract;
- (b) disrupting said cell to obtain histones;
- and
- (c) determining the level of histone acetylation.
1 more element
Dependencies are inferred from the claim text.