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AssigneeInstitute for Advanced Skin Research Inc.
InventorsHiroe Aoki, Eijiro Hara, Tetsuji Hirao
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This invention provides a pharmaceutical preparation or cosmetic, and a method for effectively inhibiting the abnormal accumulation of extra-cellular matrices. In addition, a method for preventing or treating a disease resulting from the abnormal accumulation of extra-cellular matrices is also disclosed. The pharmaceutical preparation or cosmetic contains as an effective ingredient at least one substance selected from the group consisting of the extract of a plant belonging to the genus Artemisia, the genus Forsythia, the genus Sophorak the genus Pheutn the genus GI rhiza, the genus Arctium, the genus Anemarrhena, the genus Aralia, the genus Anelicia, the genus Akebia or the genus Atractylodes, the genus Akebia or the genus Atractilodes, malotilate, 2,2'-dipyridyl and o-phenanthroline.
A method of inhibiting the abnormal accumulation of extracellular matrices in a disease process, which comprises administering a substance comprising an extract of a plant, said plant belonging to the genus Sophora, the genus said substance being present in an amount effective to inhibit the abnormal accumulation of extracellular matrices in the disease process, to a subject liable to suffer or suffering from a disease process associated with the abnormal accumulation of extracellular matrices.
A method of preventing or treating skin fibrosis, which comprises topically applying to the skin of a subject in need thereof a substance comprising an extract of a plant, said plant belonging to the genus Sophora, said substance being applied in an amount effective to inhibit the abnormal accumulation of extracellular matrices to thereby treat or prevent skin fibrosis.
Dependencies are inferred from the claim text.