Breath test for the diagnosis of Helicobacter pylori infection in the gastrointestinal tract
AssigneeOridion Medical Ltd.
InventorDaniel E. Katzman
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Abstract
A breath test for diagnosing the presence of Helicobacter pylori in a subject is described. The method of diagnosing Helicobacter pylori is performed as follows. First, a safe and effective amount of urea, preferably appropriately labelled, is administered to the subject. Second, a plurality of the exhaled breaths of the subject is analyzed to detect the concentration of a cleavage product or products, produced when urease cleaves the substrate. The measured concentrations are then fitted to a curve, and the derivative is then calculated, to indicate the presence or absence of Helicobacter pylori infection in the subject.
Claims10
A method for the diagnosis of Helicobacter Pylori in the gastrointestinal tract of a subject, comprising the steps of:
- (a) administering isotope-labeled urea to the subject, said isotope-labeled urea being cleavable by urease to form a cleavage product;
- (b) having said subject exhale repeatedly into analyzing equipment;
- (c) analyzing a plurality of exhaled breaths of the subject substantially in real time while the subject's exhalation contains the cleavage product, if present, to determine a plurality of concentrations of said cleavage product;
- and
- (d) analyzing said plurality of concentrations to indicate Helicobacter Pylori activity in the gastrointestinal tract of said subject, wherein the step of analyzing said exhaled breath of the subject is repeated substantially continuously until a predetermined accuracy for analyzing said plurality of concentrations is reached.
The method of claim;
- wherein said carbon dioxide is carbon-13 isotopically-labelled.
Dependencies are inferred from the claim text.