Boronic ester and acid compounds, synthesis and uses

A compound having the formula:

• ##STR51## or a pharmaceutically acceptable salt thereof;
• wherein P is an amino protecting group;
• A is 1;
• B.sup.1 is CH;
• X.sup.1 is --C(O)--NH--;
• X.sup.2 is --C(O)--NH--;
• R is hydrogen or alkyl;
• R.sup.1 is hydrogen, C.sub.1-8 alkyl, C.sub.3-10 cycloalkyl, C.sub.6-10 aryl, or --CH.sub.2 --R.sup.5, where the ring portion of said aryl can be optionally substituted;
• R.sup.2 is naphthylmethyl, pyridylmethyl or quinolinylmethyl;
• R.sup.3 is C.sub.4 alkyl;
• R.sup.5 is one of C.sub.6-10 aryl, C.sub.6-10 ar(C.sub.1-6)alkyl, C.sub.1-6 alk(C.sub.6-10)aryl, C.sub.3-10 cycloalkyl, C.sub.1-8 alkoxy or --W--R.sup.6, where W is a chalcogen and R.sup.6 is alkyl, where the ring portion of any of said aryl, aralkyl, or alkaryl can be optionally substituted;
• and
• Z.sup.1 and Z.sup.2 are independently one of hydroxy, alkoxy, or aryloxy, or together Z.sup.1 and Z.sup.2 form a moiety derived from a dihydroxy compound having at least two hydroxy groups separated by at least two connecting atoms in a chain or ring, said chain or ring comprising carbon atoms and, optionally, a heteroatom or heteroatoms which can be N, S, or O.