Non-iron metalloporphyrins and methods of use
AssigneeEmory University
InventorsIgor Stojiljkovic, Gordon G. Churchward
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Abstract
The present disclosure provides novel non-iron metalloporphyrins, especially those porphyrin complexes containing gallium or indium as the metal ion, and antibacterial compositions comprising artificial metalloporphyrins (such as protoporphyrin IX) completed with a metal ion selected from metal ions including, but not limited to, gadolinium, ruthenium copper, gallium, indium and manganese, and methods for inhibiting or killing bacteria and other microorganisms and for treating infections caused by microorganisms using the artificial metalloporphyrin of the present invention.
Claims20
A method for inhibiting growth of a microorganism, said method comprising the step of administering an effective amount of a composition comprising a non-iron metalloporphyrin, wherein said metalloporphyrin has a porphyrin structure as given in Formula I or Formula II, and a non-iron metal ion complexed therewith, wherein the metal ion is selected from the group consisting of a gallium ion, an indium ion, manganic ion, ruthenium ion, a copper ion and a gadolinium ion.
Dependencies are inferred from the claim text.