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US 6,066,309 AGranted
Post-labeling stabilization of radiolabeled proteins and peptides
AssigneeRhomed Incorporated
InventorsPaul O. Zamora, Michael J. Merek
Life of this patent
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Abstract
The subject invention relates to the use of ascorbic acid and derivatives thereof in stabilizing radiolabeled proteins and peptides against oxidation loss of radiolabel and autoradiolysis. Ascorbic acid is added after radiolabeling, including any required incubation period, but prior to patient administration.
Claims4
A composition comprising:
- an antibody component comprising anti-SSEA-1 IgM monoclonal antibody which has been partially reduced and stannous ion, wherein the anti-SSEA-1 IgM monoclonal antibody is labeled by the addition of .sup.99m Tc sodium pertechnetate and incubation;
- and a stabilizer component comprising 60 to 500 mg of a member selected from the group consisting of ascorbic acid and water soluble salts, esters and mixtures thereof wherein the stabilizer is added to the .sup.99m Tc-labeled anti-SSEA-1 IgM monoclonal antibody preparation subsequent to labeling the anti-SSEA-1 IgM monoclonal antibody by the addition of .sup.99m Tc sodium pertechnetate and incubation.
Dependencies are inferred from the claim text.