Back to results
US 6,063,373 AGranted
Enhanced activation of NK cells using an NK cell activator and a hydrogen peroxide scavenger or inhibitor
AssigneeMaxim Pharmaceuticals, Inc.
InventorsJan Urban Kristoffer Hellstrand, Svante Hermod Hermodsson
Life of this patent
Estimating the term…
Abstract
An improved method for the prevention of the inactivation of natural killer (NK) cells and the enhanced activation of NK cells in the presence of monocytes using a combination of a natural killer cell activator and a compound effective to inhibit the production or release of intracellular hydrogen peroxide, or a hydrogen peroxide scavenger, is disclosed. The method is useful, for example, in the treatment of solid tumors, metastases and viral infection.
Claims5
A method for treating neoplastic disease comprising the steps of:
- administering to a patient receiving radiation therapy or chemotherapy, an effective amount of an NK cell activating cytokine, wherein said cytokine is selected from the group consisting of Interleukin-1 (IL-1), Interleukin-2 (IL-2), Interleukin-12 (IL-12), Interleukin-15 (IL-15), Interferon-.alpha., Interferon-.beta. (IFN-.beta.);
- and Interferon-.gamma. (IFN-.gamma.);
- or an NK cell activating flavonoid, wherein said flavonoid is selected from the group consisting of flavone-8-acetic acid (FAA) and xanthenone4-acetic acid (XAA);
- and
- administering to the patient a compound effective to inhibit the production or release of intracellular hydrogen peroxide selected from histamine, other H.sub.2 receptor agonist and serotonin.
2 more elements
Dependencies are inferred from the claim text.