Modulation of cell proliferation and wound healing
AssigneeMedarex, Inc.
InventorPeter J. Kelleher
Life of this patent
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Abstract
Intraocular devices which are capable of sustained release of a cell proliferation modulating agent, together with methods for their preparation and use, are provided. The proliferation modulating agent is associated either covalently or non-covalently with the material from which the intraocular device is prepared, generally a biologically inert polymer which is physiologically compatible with ocular tissue. The intraocular devices are implanted in the tissue, and the drug is released from the intraocular device such that the drug is substantially retained within the implant region. The device may be used to inhibit cellular proliferation around the implant. The device can be provided as a sterile kit, preferably in a form suitable for immediate use.
Claims15
An occular implant comprising:
- a biologically inert polymer having at least one proliferation inhibiting agent associated therewith by a labile interaction selected from the group consisting of:
- a hydrophobic interaction and a hydrophilic interaction, such that upon implantation into the eye said proliferation inhibiting agent is gradually released from the implant in a localized region of the eye to thereby inhibit proliferation of target cells in the localized region of the eye.
An occular implant comprising:
- a biologically inert polymer having at least one proliferation inhibiting agent associated therewith by a labile covalent bond selected from the group consisting of:
- a hydrazone bond and a semicarbazone bond, such that upon implantation into the eye said proliferation inhibiting agent is gradually released from the implant in a localized region of the eye to thereby inhibit proliferation of target cells in the localized region of the eye.
A method for preparing an intraocular device, said method comprising:
- contacting a biologically inert polymer with a proliferation inhibiting agent, such that a labile interaction selected from the group consisting of:
- hydrazone bond, a semicarbazone bond, a hydrophobic interaction, and a hydrophilic interaction between said polymer and said proliferation inhibiting agent results.
Dependencies are inferred from the claim text.