Polymerized liposomes targeted to M cells and useful for oral or mucosal drug delivery
AssigneeMassachusetts Institute of Technology
InventorsHongming Chen, Robert S. Langer
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Abstract
The present invention relates to targeted polymerized liposomes for oral and/or mucosal delivery of vaccines, allergens and therapeutics. In particular, the present invention relates to polymerized liposomes which have been modified on their surface to contain a molecule or ligand which targets the polymerized liposome to a specific site or cell type. More particularly, the invention relates to the use of polymerized liposomes modified to contain a carbohydrate or lectin on their surface.
Claims23
Polymerized liposomes comprising a phospholipid bilayer having covalently bonded phospholipids, an aqueous core and a lectin wherein the lectin is Ulex Europeans Agglutinin I.
A method of delivering therapeutic molecules to an animal which comprises administering to said animal polymerized liposomes comprising a phospholipid bilayer having covalently bonded phospholipids;
- an aqueous core;
- a lectin wherein the lectin is Ulex Europeans Agglutinin(UEA) therapeutic molecule.
A method of orally delivering therapeutics to a mammal which comprises administering to said mammal a polymerized liposome comprising a polymerized phospholipid bilayer, therapeutic agent encapsulated in an aqueous core of said liposome and a lectin wherein the lectin is Ulex Europeans Agglutinin(UEA).
Dependencies are inferred from the claim text.