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US 6,060,048 AGranted
Method for transplanting cells into the brain and therapeutic uses therefor
AssigneeNew York University
InventorBruce D. Cherksey
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AssigneeNew York University
InventorBruce D. Cherksey
Estimating the term…
A method for grafting a cell in the brain of a mammalian subject is accomplished by attaching the cell to a support matrix so that the cell attaches to the matrix surface, and implanting the support matrix with the attached cell into the brain. Preferred support matrices are glass or plastic microbeads, either solid or porous, having a diameter from about 90 to about 125 .mu.m. The method employs cells of different types, preferably cells of neural or paraneural origin, such as adrenal chromaffin cells. Also useful are cell lines grown in vitro. Cells not of neural or paraneural origin, such as fibroblasts, may also be used following genetic alteration to express a desired neural product such as a neurotransmitter or a neuronal growth factor. The method is used to treat neurological diseases such as Parkinson's disease, Alzheimer's disease, Huntington's disease, epilepsy, and traumatic brain injury.
A method for providing a neurally-active molecule to a mammal comprising
A method for providing dopamine to a mammal comprising injecting a multiplicity of supports containing an effective number of viable cells adhered to surfaces of the supports, wherein:
A method for providing dopamine to a mammal comprising:
A method of transplanting cells into a mammal having a disease or dysfunction responsive to a neurally-active molecule, comprising introducing a multiplicity of supports containing an effective number of viable cells that secrete said neurally active molecule adhered to surfaces of the supports, wherein:
A method for providing a neurally-active molecule to a mammal comprising introducing a multiplicity of supports containing an effective number of viable cells that provide said neurally-active molecule, adhered to surfaces of the supports, wherein:
Dependencies are inferred from the claim text.