Therapeutic liposome composition and method of preparation
AssigneeSequus Pharmaceuticals, Inc.
InventorsTheresa M. Allen, Paul Uster, Francis J. Martin, Samuel Zalipsky
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Abstract
Reagents for use in preparing a therapeutic liposome composition sensitized to a target cell are described. The reagents include a liposomal composition composed of pre-formed liposomes having an entrapped therapeutic agent and a plurality of targeting conjugates composed of a lipid, a hydrophilic polymer and a targeting ligand. The therapeutic, target-cell sensitized liposome composition is formed by incubating the liposomal composition with a selected conjugate.
Claims19
A kit containing reagents for use in preparing a therapeutic liposome composition sensitized to a target cell, comprising
- a liposomal composition composed of pre-formed liposomes having an entrapped therapeutic agent;
- and
- a plurality of conjugates, each conjugate composed of (i) a lipid having a polar head group and a hydrophobic tail, (ii) a hydrophilic polymer having a proximal end and a distal end, said polymer attached at its proximal end to the head group of the lipid, and (iii) a targeting ligand attached to the distal end of the polymer;
- wherein a therapeutic, target-cell sensitized liposome composition is formed by incubating the liposomal composition with a selected conjugate.
Dependencies are inferred from the claim text.