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US 6,054,142 AGranted
Biocompatible devices with foam scaffolds
AssigneeCyto Therapeutics, Inc.
InventorsRebecca Li, Tyrone F. Hazlett
Life of this patent
Estimating the term…
Abstract
A biocompatible cell device having an internal foam scaffold to provide a growth surface for encapsulated cells which produce a biologically active molecule.
Claims45
A biocompatible device for providing encapsulated animal cells comprising:
- (a) a core comprising:
- (1) a reticulate thermoplastic or thermoplastic elastomer foam scaffold having interconnected pores,
- (A) at least some of said interconnected pores being cell-permissive pores having a diameter between 20 and 500 .mu.m such that the pore size is sufficient to permit cell attachment within the pores, and
- (B) at least some of said interconnected pores having a diameter less than 10 .mu.m, such that the pore size is cell-impermissive and of a size insufficient to permit cell attachment within the pores, and
- (2) a first population of living animal cells dispersed in the cell-permissive pores, the animal cells being capable of secreting a biologically active molecule or providing a biological function;
- (b) a biocompatible polymer or hydrogel jacket which encapsulates the cell growth matrix,
- (1) the jacket comprising at least one selectively permeable membrane surface having a molecular weight cut-off (MWCO) of 50-1000 kD, which permits passage of substances thereacross;
- and
- (2) the jacket being impermeable to said cells.
6 more elements
A method for delivering a biologically active molecule or providing a biological function to a recipient comprising implanting at least one biocompatible device in the recipient, the device comprising:
- (a) a core comprising:
- (1) a reticulate thermoplastic or thermoplastic elastomer foam scaffold having interconnected pores,
- (A) at least some of said interconnected pores being cell-permissive pores having a diameter between 20 and 500 .mu.m such that the pore size is sufficient to permit cell attachment within the pores and
- (B) at least some of said interconnected pores having a diameter less than 10 .mu.m, such that the pore size is cell-impermissive and of a size insufficient to permit cell attachment within the pores, and
- (2) a first population of living animal cells dispersed in the cell-permissive pores, the animal cells being capable of secreting a biologically active molecule or providing a biological function;
- (b) a biocompatible polymer or hydrogel jacket which encapsulates the cell growth matrix,
- (1) the jacket comprising at least one selectively permeable membrane surface having a MWCO of 50-1000 kD, which permits passage of substances thereacross;
- and
- (2) the jacket being impermeable to said animal cells.
6 more elements
Dependencies are inferred from the claim text.