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US 6,051,689 AGranted
Receptor for the glucagon-like-peptide (GLP-1)
AssigneeNovo Nordisk A/S
InventorBernard Thorens
Life of this patent
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Abstract
The present invention relates to a recombinant glucagonlike peptide-1 (GLP-1) receptor having the nucleotide sequence of SEQ ID NO:1 or SEQ ID NO:3, wherein the receptor polypeptide binds GLP-1 with a Kd of less than 100 nM.
Claims2
An isolated glucagon-like peptide-1 (GLP-1) receptor polypeptide comprising the amino acid sequence of a naturally-occurring mammalian GLP-1 receptor protein or of a fragment thereof, wherein the receptor protein or fragment is encoded by a cDNA molecule that is isolated from a mammalian library and comprises the nucleotide sequence shown in SEQ ID NO:
- 1 or SEQ ID NO:
- 3, and wherein said receptor polypeptide binds GLP-1 with a K.sub.D of less than 100 nM.
Dependencies are inferred from the claim text.