US 6,051,609 A · Additives enhancing the effect of therapeutic agents

Abstract

Composition and method for enhancing therapeutic effects of topically applied agents are disclosed. The cosmetic or therapeutic composition may include one or more of cosmetic or pharmaceutical agents present in a total amount of from 0.01 to 40 percent and one or more of hydroxycarboxylic acids or related compounds present in a total amount of from 0.01 to 99 percent by weight of the total composition. The cosmetic and pharmaceutical agents may include but not limited to age spots, wrinkles and keratoses removing agents; vitamins; aloes; sun screens; tanning, depigmenting and shampooing agents; antiyeasts; antifungal, antibacterial and antiviral agents; topical bronchial dilators and topical cardiovascular agents; hormonal agents; vasodilators; retinoids and other dermatological agents. The hydroxycarboxylic acids and related compounds include organic alpha and beta hydroxycarboxylic acids, alpha and beta ketocarboxylic acids and salts thereof. Topical application of the cosmetic or therapeutic composition has been found to achieve a substantial increase in cosmetic or therapeutic effect of the active ingredient in humans and domesticated animals.

Claims69

Dependent claims

A topically effective skin treating composition prepared by:

combining, simultaneously or in any order, at least one first ingredient with at least one second ingredient;
said first ingredient selected from the group consisting of anti-psoriatic agents, anti-dermatitis agents, anti-inflammatory agents other than topical corticosteriods, antihistamines, anti-pruritic agents and local anesthetics;
said second ingredient comprising an enhancing amount of at least one member selected from the group consisting of hydroxycarboxylic acids, lactones and salts thereof and related ketocarboxylic acids, esters, and salts thereof.

A method of enhancing the effect of a composition comprising a first ingredient selected from the group consisting of anti-psoriatic agents, anti-dermatitis agents, anti-inflammatory agents other than topical corticosterioids, antihistamines, anti-pruritic agents and local anesthetics, in a topically acceptable vehicle for the topical administration to a person in need thereof, comprising combining with said composition an enhancing amount of at least one second ingredient selected from the group consisting of hydroxycarboxylic acids, lactones and salts thereof and related ketocarboxylic acids, esters, and salts thereof.

A method for topically treating skin conditions or disorders comprising topically applying a composition to said skin, said composition being prepared by:

combining, simultaneously or in any order, a first ingredient selected from the group consisting of anti-psoriatic agents, anti-dermatitis agents, anti-inflammatory agents other than topical corticosteriods, antihistamines, anti-pruritic agents and local anesthetics, with at least one second ingredient;
said second ingredient comprising a composition consisting essentially of an enhancing amount of at least one member selected from the group consisting of hydroxycarboxylic acids, lactones and salts thereof and related ketocarboxylic acids, esters, and salts thereof.

Dependencies are inferred from the claim text.

Additives enhancing the effect of therapeutic agents

Life of this patent

Additives enhancing the effect of therapeutic agents

Life of this patent

Abstract

Claims69