Means to achieve sustained release of synergistic drugs by conjugation
AssigneeUniversity of Kentucky Research Foundation
InventorsPaul Ashton, Peter Anthony Crooks, Tadeusz Cynkowski, Grazyna Cynkowska, Hone Guo
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Abstract
A codrug composition of at least two drug compounds covalently linked to one another via a labile bond to form a single codrug composition, or ionically linked to one another to form a single workings composition, and methods of use of the codrug for the treatment of various medical conditions. The codrug may be administered by itself or in the form of a bioerodible or nonbioerodible substance.
Claims37
A sustained release, and substantially inactive codrug, comprising at least two drugs ionically or covalently linked to one another wherein each active drug is regenerated upon bond cleavage.
A sustained release, and substantially inactive codrug, comprising at least two drugs covalently linked to one another wherein each active drug is regenerated upon bond cleavage.
Dependencies are inferred from the claim text.