Conformationally constrained backbone cyclized somatostatin analogs
AssigneePeptor Limited
InventorsVered Hornik, Gary Gellerman, Mich El M Afargan
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Abstract
Novel peptides which are conformationally constrained backbone cyclized somatostatin analogs. Methods for synthesizing the somatostatin analogs and for producing libraries of the somatostatin analogs are also disclosed. Furthermore, pharmaceutical compositions comprising somatostatin analogs, and methods of using such compositions are disclosed.
Claims15
A backbone cyclized somatostatin analog comprising a peptide sequence of four to twelve amino acids that incorporates at least two building units, each of which contains one nitrogen atom of the peptide backbone connected to a bridging group comprising an amide, thioether, thioester or disulfide, wherein the at least two building units are connected to the bridging group to form a cyclic structure.
Dependencies are inferred from the claim text.