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US 6,051,378 AGranted
Methods of screening nucleic acids using mass spectrometry
AssigneeGenetrace Systems, Inc.
InventorsJoseph Albert Monforte, Thomas Andrew Shaler, Yuping Tan, Christopher Hank Becker
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Abstract
This invention relates to methods for screening nucleic acids for mutations by analyzing nonrandomly fragmented nucleic acids using mass spectrometric techniques and to procedures for improving mass resolution and mass accuracy of these methods of detecting
Claims31
A method of detecting mutations in a target nucleic acid comprising:
- obtaining from said target nucleic acid, a set of nonrandom length fragments (NLFs) in single stranded form, wherein said set comprises NLFs derived from a single-stranded or double-stranded target nucleic acid, wherein said set of single stranded NLFs does not comprise the entirety of fragments generated from non-randomly fragmenting a double-stranded target nucleic acid, and determining masses of the members of said set using mass spectrometry.
Dependencies are inferred from the claim text.