Blockade of T lymphocyte down-regulation associated with CTLA-4 signaling
AssigneeThe Regents of the University of California Office of Technology Transfer
InventorsJames Patrick Allison, Dana R. Leach, Matthew F. Krummel
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Abstract
T cell activation in response to antigen is increased by the administration of binding agents that block CTLA-4 signaling. When CTLA-4 signaling is thus blocked, the T cell response to antigen is released from inhibition. Such an enhanced response is useful for the treatment of tumors, chronic viral infections, and as an adjuvant during immunization.
Claims23
A method for inhibiting the growth of non-T cell tumor cells in a mammalian host, comprising:
- administering to said mammalian host an immune response stimulating agent and a CTLA-4 blocking agent, said CTLA-4 blocking agent characterized as specifically binding to the extracellular domain of CTLA-4 and inhibitory of CTLA-4 signaling;
- wherein said administration is effective to inhibit the growth of non-T cell tumor cells in said mammalian host.
A method for increasing the T cell response of a mammalian host to antigenic stimulation, comprising:
- administering to said mammalian host an immune response stimulating agent and a CTLA-4 blocking agent characterized as specifically binding to the extracellular domain of CTLA-4 and inhibitory of CTLA-4 signaling;
- wherein said administration is effective to increase the T cell response of said mammalian host to antigenic stimulus.
A method for inhibiting the growth of non-T cell tumor cells in a mammalian host, comprising:
- administering simultaneously or sequentially to said mammalian host a chemotherapeutic agent and a CTLA-4 blocking agent, said CTLA-4 blocking agent characterized as specifically binding to the extracellular domain of CTLA-4 and inhibitory of CTLA-4 signaling;
- wherein said administration is effective to inhibit the growth of non-T cell tumor cells in said mammalian host.
A method for increasing the response of a mammalian T cell from a mammalian host to antigenic stimulation, comprising:
- obtaining a mammalian T cell from a mammalian host;
- contacting said mammalian T cell ex vivo with an immune response stimulating agent and a CTLA-4 blocking agent, said CTLA-4 blocking agent characterized as specifically binding to the extracellular domain of CTLA-4 and inhibitory of CTLA-4 signaling, wherein said contacting is effective to increase the response of said mammalian T cell to antigenic stimulus;
- and
- administering said mammalian T cell to said host.
Dependencies are inferred from the claim text.