Cyclodextrin polymers for carrying and releasing drugs

A method for producing a controlled release pharmaceutical composition comprising;

• a) combining cyclodextrin molecules selected from the group consisting of cyclodextrin derivatives, cyclodextrin dimers, cyclodextrin trimers, and cyclodextrin polymers with an active agent consisting of a nucleic acid, to form an inclusion complex between the cyclodextrin molecules and the active agent, and
• b) covalently cross-linking the cyclodextrin molecules through a biocleavable linkage selected from the group consisting of a disulfide linkage, a protected disulfide linkage, an ester linkage and a hydrazone linkage, to form a polymer that has completely entrapped the active agent and wherein the cross-linking provides the function of controlled release.

A method for producing a controlled release pharmaceutical composition comprising;

• a) combining cyclodextrin molecules selected from the group consisting of cyclodextrin derivatives, cyclodextrin dimers, cyclodextrin trimers, and cyclodextrin polymers with an active agent consisting of a toxin, to form an inclusion complex between the cyclodextrin molecules and the active agent, and
• b) covalently cross-linking the cyclodextrin molecules through a biocleavable linkage selected from the group consisting of a disulfide linkage, a protected disulfide linkage, an ester linkage and a hydrazone linkage, to form a polymer that has completely entrapped the active agent and wherein the cross-linking provides the function of controlled release.