Loading patent…
AssigneePharmacia & Upjohn Company
InventorsJohanna Dalborg, Helena Sandberg, Anna-Lisa Smeds, Eva kerblom
Estimating the term…
Processes for improving the in vivo function of factor VIII by shielding exposed targets of the factor VIII comprise a) immobilizing the factor VIII by interaction with a group-specific adsorbent carrying ligands manufactured by organic-chemical synthesis, for preventing polymer coupling to reactive amino acids of the immobilized factor VIII, within or adjacent to interaction domains; b) activating a biocompatible polymer; c) conjugating the activated biocompatible polymer to external sites of the immobilized factor VIII; and thereafter d) eluting the conjugate from the adsorbent. Processes for administering factor VIII comprise subcutaneously, intramuscularly, intradermally or intravenously administering a conjugate of factor VIII and a biocompatible polymer, and methods for treatment of hemophilia A comprise subcutaneous, intramuscular, intradermal or intravenous administration of a conjugate of factor VIII and a biocompatible polymer.
A process for improving the in vivo function of factor VIII by shielding exposed targets of the factor VIII, comprising
A process for administering factor VIII, comprising subcutaneously, intramuscularly, or intradermally administering a conjugate of factor VIII and a biocompatible polymer eluted from an adsorbent on which is formed a conjugate of the biocompatible polymer and immobilized factor VIII, the factor VIII being immobilized by interaction with group-specific ligands manufactured by organic-chemical synthesis on the adsorbent, for preventing polymer coupling to reactive amino acids of the immobilized factor VIII, within or adjacent to interaction domains.
A process for administering factor VIII, comprising intravenously administering a conjugate of factor VIII and a biocompatible polymer eluted from an adsorbent on which is formed a conjugate of the biocompatible polymer and immobilized factor VIII, the factor VIII being immobilized by interaction with group-specific ligands manufactured by organic-chemical synthesis on the adsorbent, for preventing polymer coupling to reactive amino acids of the immobilized factor VIII, within or adjacent to interaction domains.
Method for treatment of hemophilia A, comprising subcutaneous, intramuscular, intradermal or intravenous administration of a conjugate of factor VIII and a biocompatible polymer eluted from an adsorbent on which is formed a conjugate of the biocompatible polymer and immobilized factor VIII, the factor VIII being immobilized by interaction with group-specific ligands manufactured by organic-chemical synthesis on the adsorbent, for preventing polymer coupling to reactive amino acids of the immobilized factor VIII, within or adjacent to interaction domains.
Dependencies are inferred from the claim text.