US 6,046,211 A · Amidino derivatives useful as nitric oxide synthase inhibitors

Amidino derivatives useful as nitric oxide synthase inhibitors

AssigneeG.D. Searle & Co.

InventorsDonald W. Hansen, Jr., Mark G. Currie, E. Ann Hallinan, Kam F. Fok, Timothy J. Hagen, Arija A. Bergmanis, Steven W. Kramer, Len F. Lee, Suzanne Metz, William M. Moore, Karen B. Peterson, Barnett S. Pitzele, Dale P. Spangler, R. Keith Webber, Mihaly V. Toth, Mahima Trivedi, Foe S. Tjoeng

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Abstract

The current invention discloses useful pharmaceutical compositions containing amidino derivative useful as nitric oxide synthase inhibitors.

Claims9

Dependent claims

A compound of the formula:

##STR337## wherein R1 and R2 form an alicyclic radical;
n is 2;
and
X is a lower alkylene of one carbon optionally substituted with lower alkyl, lower alkoxy, amino, hydroxy, or haloalkyl.

1 more element

Dependencies are inferred from the claim text.

Facts

Application

09/073,929Filed 6 May 1998 · division

Granted

4 Apr 2000

Term ends

Not estimatedThe source records don’t support an estimate.

Classification45 codes

C07D 213/06
Having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring…
A61K 31/395
Heterocyclic compounds: having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
A61K 31/40
Having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins: having five-membered rings with one nitrogen as the only ring hetero atom,…
A61K 31/415
Having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole: 1,2-Diazoles