Formulations and methods for providing prolonged local anesthesia
AssigneeChildren's Medical Center Corporation
InventorsCharles B. Berde, Robert S. Langer, Joanne Curley, Jenny Castillo
Life of this patent
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Abstract
The use of glucocorticosteroids in methods and formulations for prolonging and/or reactivating local anesthesia or local anesthesia previously induced by a local anesthetic agent, is disclosed.
Claims60
A method for reactivating or prolonging local anesthesia at a site in a patient in need thereof, comprising
- administering to a patient at a site at which local anesthesia is desired, a pharmaceutically acceptable composition comprising an effective amount of a local anesthetic, and thereafter
- administering a glucocorticosteroid agent, in an amount effective to reactivate or prolong local anesthesia, said glucocorticosteroid agent being administered at a time ranging from about 1 to about 72 hours after said local anesthetic was administered.
In a method for providing local anesthesia in a patient by administering an effective amount of a local anesthetic and an amount of a glucocorticoid agent effective to prolong the induced local anesthesia, the improvement consisting of administering a glucocorticosteroid in a time period ranging from about 1 to about 12 hours after the local anesthetic is administered, said glucocorticosteroid being administered in an amount effective to prolong or reactivate said anesthetic effect.
A pharmaceutical formulation for providing local anesthesia in a patient, comprising an amount of a local anesthetic effective to induce local anesthesia at an appropriate site in a patient in need thereof and an amount of a glucocorticosteroid effective to reactivate or prolong said local anesthesia, said local anesthetic and said glucocorticosteroid provided in controlled release form, such that said glucocorticosteroid is released beginning at a time period ranging from about 1 to about 72 hours after said local anesthetic is released, said glucocorticosteroid being included in said formulation in an amount effective to prolong or reactivate said local anesthesia provided by said local anesthetic.
Dependencies are inferred from the claim text.