Polyoma virus pseudocapsids and method to deliver material into cell
AssigneeCaduceus Limited
InventorsJitka Forstova, Beverly Elayne Griffin, Nina Sheila Krauzewicz
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Abstract
The present invention relates to biologically useful material in the form of a pseudocapsid formed from papovavirus major capsid antigen and excluding minor capsid antigens, which pseudocapsid incorporates exogenous material. The invention also relates to a method of using the pseudocapsids as vectors for exogenous material transfer, especially gene transfer in the therapy of genetic disorders, or other uses such as antibody or drug targeting.
Claims8
A method of transferring material into a host cell comprising:
- providing a pseudocapsid formed from polyoma virus major capsid antigen VP1 and excluding minor capsid antigens, which pseudocapsid has exogenous material associated therewith;
- and
- treating the host cell with the pseudocapsid so that the material is taken up by the cell and is biologically functional in that cell.
A pseudocapsid formed from polyoma virus major capsid antigen VP1 and excluding minor capsid antigens, which pseudocapsid has exogenous material associated therewith, wherein the exogenous material is genetic material, wherein the exogenous material does not consist of a neo gene, and wherein the pseudocapsid transfers the exogenous material into a host cell so that the material is taken up by the cell and is biologically functional in the cell.
Dependencies are inferred from the claim text.