Antisense modulation of PI3 kinase p110 delta expression
AssigneeIsis Pharmaceuticals, Inc.
InventorsBrett P. Monia, Lex M. Cowsert
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Abstract
Antisense compounds, compositions and methods are provided for modulating the expression of PI3 kinase p110 delta. The compositions comprise antisense compounds, particularly antisense oligonucleotides, targeted to nucleic acids encoding PI3 kinase p110 delta. Methods of using these compounds for modulation of PI3 kinase p110 delta expression and for treatment of diseases associated with expression of PI3 kinase p110 delta are provided.
Claims25
An antisense compound 8 to 30 nucleobases in length targeted to the 3'UTR of a nucleic acid molecule encoding human PI3 kinase p110 delta, wherein solid antisense compound specifically hybridizes with and inhibits the expression of human PI3 kinase p110 delta.
An antisense oegonucleotide up to 30 nucleobases in length targeted to a nucleic acid molecule encoding human PI3 kinase p110 delta comprising at least an 8 nucleobase portion of SEQ ID NO:10, 15, 22, 23, 24, 27, 28, 30, 31, 33, 11, 13, 14, 16, 20, 21, 26, 29, 32, 34, 35, 36 or 38 and which inhibits the expression of human PI3 kinase p110 delta.
Dependencies are inferred from the claim text.