Methods and systems for treating ischemia
AssigneeSalient Interventional Systems, Inc.
InventorBrian Douglas Lewis
Life of this patent
Estimating the term…
Abstract
Methods for treating total and partial occlusions employ a perfusion conduit which is penetrated through the occlusive material. Oxygenated blood or other medium is then perfused through the conduit to maintain oxygenation and relieve ischemia in tissue distal to the occlusion. Optionally, the occlusion may be treated while perfusion is maintained, typically by introducing a thrombolytic or other agent into the occlusive material using the perfusion conduit. Such methods are particularly suitable for treating acute stroke to prevent irreversible damage to the cerebral tissue.
Claims53
A method for treating a patient having ischemia resulting from a pre-existing blockage in a blood vessel, said method comprising:
- penetrating a perfusion conduit through the blockage, wherein the perfusion conduit is free from external balloons;
- and
- pumping an oxygenated medium through the conduit at a rate or pressure sufficient to relieve ischemia but below that which would cause injury distal to the occlusion.
A method for treating a patient having ischemia resulting from an occlusion in the cerebral vasculature, said method comprising:
- percutaneously introducing a conduit into the patient's vasculature;
- guiding a distal port on the conduit through the occlusion, wherein the conduit is free from external balloons;
- obtaining oxygenated blood from the patient;
- and
- perfusing the blood back to the patient through the distal port of the conduit past the occlusion at a rate sufficient to relive the ischemia but below that which would cause injury distal to the occlusion.
A method for treating a patient having ischemia resulting from an abrupt occlusion in the cerebral vasculature, said method comprising:
- percutaneously introducing a perfusion conduit into the patient's vasculature within six hours of the occurrence of the abrupt occlusion;
- guiding a distal port on the conduit through the occlusion;
- obtaining oxygenated blood from the patient;
- and
- perfusing the blood back to the patient through the distal port of the conduit past the occlusion at a rate sufficient to relive the ischemia, wherein the pumping rate is controlled to maintain pressure downstream of the occlusion at a control point within the range from 50 mmHg to 300 mmHg.
Dependencies are inferred from the claim text.