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US 6,043,344 AGranted
Human CTLA-8 and uses of CTLA-8-related proteins
AssigneeGenetics Institute, Inc.
InventorsKenneth Jacobs, Kerry Kelleher, McKeough Carlin, Samuel Goldman, Debra Pittman, Sha Mi, Steven Neben, Joanne Giannotti, Margaret M. Golden-Fleet
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Abstract
Polynucleotides encoding human CTLA-8 and related proteins are disclosed. Human CTLA-8 proteins and methods for their production are also disclosed. Methods of treatment using human CTLA-8 proteins, rat CTLA-8 proteins and herpesvirus herpes CTLA-8 proteins are also provided.
Claims13
An isolated human CTLA-8 protein comprising an amino acid sequence selected from the group consisting of:
- (a) the amino acid of SEQ ID NO:2;
- (b) the amino acid sequence of SEQ ID NO:2 from amino acids 11 to 163;
- (c) the amino acid sequence of SEQ ID NO:2 from amino acids 29 to 163;
- (d) the amino acid sequence of SEQ ID NO:2 from amino acids 31 to 163;
- (e) a fragment of SEQ ID NO:2, the fragment comprising amino acids 11-163 of SEQ ID NO:2;
- (f) a fragment of SEQ ID NO:2, and the fragment comprising amino acids 29-163 of SEQ ID NO:2;
- (g) a fragment of SEQ ID NO:2, the fragment comprising amino acids 31-163 of SEQ ID NO:2.
4 more elements
A human CTLA-8 protein produced according to a process which comprises the steps of:
- (a) growing a culture of a cell in a suitable culture medium, wherein the cell is transformed with a polynucleotide operably linked to an expression control sequence, wherein the polynucleotide is selected from the group consisting of:
- (aa) a polynucleotide comprising the nucleotide sequence of SEQ ID NO:1 from nucleotide 55 to nucleotide 544;
- (ab) a polynucleotide comprising the nucleotide sequence of SEQ ID NO:1 from nucleotide 146 to nucleotide 544;
- (ac) a polynucleotide comprising the nucleotide sequence of the full-length protein coding sequence of clone B18 deposited under accession number ATCC 69868;
- (ad) a polynucleotide encoding the fill length protein encoded by the cDNA insert of clone B18 deposited under accession number ATCC 69868;
- and
- (ae) a polynucleotide comprising a nucleotide sequence varying from the sequence of the nucleotide sequence specified in (aa)-(ad) as a result of degeneracy of the genetic code;
- and
- (b) purifying the human CTLA-8 protein encoded by said polynucleotide from the culture.
6 more elements
Dependencies are inferred from the claim text.