Isoxazolyl endothelin antagonists
AssigneeBristol-Myers Squibb Company
InventorsNatesan Murugesan, Joel C. Barrish, Zhengxiang Gu, Richard A. Morrison
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Abstract
The compounds N-[[2'-[[(4,5-dimethyl-3-isoxazolyl)amino]sulfonyl]-4-(2-oxazolyl)[1,1'-bi phenyl]-2-yl]methyl]-N,3,3-trimethylbutanamide and N-(4,5-dimethyl-3-isoxazolyl)-2'-[(3,3-dimethyl-2-oxo-1-pyrrolidinyl)methy l]-4'-(2-oxazolyl)[1,1'-biphenyl]-2-sulfonamide, and salts thereof, useful as endothelin antagonists.
Claims55
The compound N-[[2'-[[(4,5-dimethyl-3-isoxazolyl)amino]sulfonyl]-4-(2-oxazolyl)[1,1'-bi phenyl]-2-yl]methyl]-N,3,3-trimethylbutanamide or a salt thereof.
The compound which is N-(4,5-dimethyl-3-isoxazolyl)-2'-formyl-N-[(2-methoxyethoxy)methyl]-4'-(2- oxazolyl)[1,1'-biphenyl]-2-sulfonamide.
The compound which is N-(4,5-dimethyl-3-isoxazolyl)-2'-formyl-4'-(2-oxazolyl)[1,1'-biphenyl]-2-s ulfonamide.
The compound which is N-(4,5-dimethyl-3-isoxazolyl)-2'-[(methylamino)methyl]-4'-(2-oxazolyl)[1,1 '-biphenyl]-2-sulfonamide.
The compound N-(4,5-dimethyl-3-isoxazolyl)-2'-[(3,3-dimethyl-2-oxo-1-pyrrolidinyl)methy l]-4'-(2-oxazolyl)[1,1'-biphenyl]-2-sulfonamide or a salt thereof.
The compound which is N-(4,5-dimethyl-3-isoxazolyl)-2'-(hydroxymethyl)-N-[(2-methoxyethoxy)methy l]-4'-(2-oxazolyl)[1,1'-biphenyl]-2-sulfonamide.
The compound which is 2'-(bromomethyl)-N-(4,5-dimethyl-3-isoxazolyl)-N-[(2-methoxyethoxy)methyl] -4'-(2-oxazolyl)[1, 1'-biphenyl]-2-sulfonamide.
The compound which is N-(4,5-dimethyl-3-isoxazolyl)-2'-[(3,3-dimethyl-2-oxo-1-pyrrolidinyl)methy l]-N-[(2-methoxyethoxy)methyl]-4'-(2-oxazolyl)[1,1'-biphenyl]-2-sulfonamide
The compound which is 4-[[[2'-[[(4,5-dimethyl-3-isoxazolyl)amino]sulfonyl]-4-(2-oxazolyl)[1,1'-b iphenyl]-2 yl]methyl]amino]-2,2-dimethylbutanoic acid.
Dependencies are inferred from the claim text.