Effect of electric field and ultrasound for transdermal drug delivery
AssigneeMassachusetts Institute of Technology
InventorsJoseph Kost, Uwe Pliquett, Samir S. Mitragotri, Robert S. Langer, James C. Weaver
Life of this patent
Estimating the term…
Abstract
Transdermal transport of molecules during sonophoresis (delivery or extraction) can be further enhanced by application of an electric field, for example, electroporation or iontophoresis. In a preferred embodiment the ultrasound is low frequency ultrasound which induces cavitation of the lipid layers of the stratum corneum (SC). This method provides higher drug transdermal fluxes, allows rapid control of transdermal fluxes, and allows drug delivery or analyte extraction at lower ultrasound intensities than when ultrasound is applied in the absence of an electric field.
Claims10
A method for enhancing transdermal transport of compounds comprising administering to the skin an effective amount of ultrasound at a frequency of less than 2.5 MHz to permeabilize the skin followed by an enhancer selected from the group consisting of electroporation, vacuum or mechanical pressure.
Dependencies are inferred from the claim text.