Compounds and their compositions having anti-inflammatory and anti-thrombotic activities

A compound of the formula:

• A--X.sub.1 --NO.sub.2
• or salts, wherein;
• A=R(COX).sub.t, wherein t=0 or 1;
• X=O, NH, NR.sub.1c, wherein R.sub.1c is a linear or branched C.sub.1 -C.sub.10 alkyl group ##STR11## wherein m and n are an integer from 1 to 6;
• wherein R.sub.2a is H or CH.sub.3 ;
• and wherein the linking with X.sub.1 can be in any position of the ring;
• R is:
• ##STR12## wherein:
• X.sub.0 =X;
• R.sub.1 is OCOR.sub.3 ;
• wherein R.sub.3 is methyl, ethyl, linear or branched C.sub.3 -C.sub.5 alkyl, or the residue of an etherocycle with only one ring having 5 or 6 atoms which can be aromatic, partially or completely hydrogenated, containing one or more ethero-atoms selected independently among O, N and S;
• R.sub.2 is hydrogen, hydroxy, halogen, linear or branched C.sub.1-4 alkyl, linear or branched C.sub.1 -C.sub.4 alkoxyl;
• a linear or branched C.sub.1 -C.sub.4, perflouroalkyl, nitro, amino, mono- or dialkylamine with C.sub.1-4 alkyl;
• or R.sub.1 and R.sub.2 together are dioxymethylene group;
• n.sub.I is an integer 0 or 1;
• X.sub.1 in the formula A--X.sub.1 --NO.sub.2, is a bivalent connecting bridge selected from the group consisting of --YO-- where Y is a linear or branched C.sub.1-20 alkylene, or a substituted or unsubstituted C.sub.5-7 cycloalkylene;
• and ##STR13## wherein n is an integer from 1 to 6, R.sub.2a is an defined above;
• Y is as defined above, and r=0 or 1;
• with the proviso that when X=NH, then Y is only ethylene and R.sub.2 is hydrogen;
• and with the proviso that R.sub.1 cannot be OCOR.sub.3, in position 2 when R.sub.3 is methyl.