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AssigneeYale University
InventorsAlan C. Sartorelli, Krishnamurthy Shyam, Philip G. Penketh, Shu-Hui Chen
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The present invention relates to a compound of the formula wherein R.sup.1 and R.sup.2 are selected from lower alkyl groups having 1-6 carbon atoms, substituted or unsubstituted aryl groups, and unsaturated alkyl groups having 1-6 carbon atoms; R.sup.3 is a substituted or unsubstituted lower alkyl group having 1-6 carbons; and R.sup.4 is selected from substituted or unsubstituted lower alkyl groups having 1-6 carbon atoms, substituted or unsubstituted aryl groups, and unsaturated alkyl groups having 1-6 carbon atoms. The present invention also relates to a pharmaceutical composition comprising the above compound, as well as a method of treating tumor cells with the compound.
A compound of the formula ##STR20## wherein R.sup.1 is selected from the group consisting of lower alkyl groups having 1-6 carbon atoms, substituted or unsubstituted aryl groups, and unsaturated alkyl groups having 2-6 carbon atoms;
A pharmaceutical composition for treating tumor cells, comprising an antineoplastic agent in a pharmaceutically acceptable carrier, said antineoplastic agent having the formula ##STR23## wherein R.sup.1 is selected from the group consisting of lower alkyl groups having 1-6 carbon atoms, substituted or unsubstituted aryl groups, and unsaturated alkyl groups having 2-6 carbon atoms;
A method of inhibiting the growth of L1210 leukemia or EMT6 mammary carcinoma in host organisms, comprising the step of administering to said host organism a growth-inhibiting effective amount of an antineoplastic agent in a carrier, said antineoplastic agent having the formula ##STR26## wherein R is selected from the group consisting of methyl, 2-chloroethyl, vinyl, phenyl, p-tolyl, chlorophenyl, p-methoxyphenyl, p-nitrobenzyl, benzyl, 4,5-dimethoxy-2-nitrobenzyl, 1-(4-nitrophenyl)ethyl, and a substituent of the formula ##STR27## or a pharmaceutically acceptable salt thereof.
A compound of the formula ##STR28## wherein R.sup.1 and R.sup.2 are each methyl;
A pharmaceutical composition for treating tumor cells, comprising an antineoplastic agent in a pharmaceutically acceptable carrier, said antineoplastic agent having the formula ##STR29## wherein R.sup.1 and R.sup.2 are each methyl;
Dependencies are inferred from the claim text.