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US 6,039,975 AGranted
Colon targeted delivery system
AssigneeHoffman-La Roche Inc.
InventorsNavnit Hargovindas Shah, Aruna M. Railkar, Wantanee Phuapradit
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Abstract
A novel delivery system for targeting drugs to the colon is herein described. The system is a tablet comprised of three parts: 1) an outer enteric coating, 2) an inner semi-permeable polymer membrane containing a plasticizer and 3) a central core comprising swelling excipients and an active ingredient. The novel dosage form described herein will release the drug consistently in the colon by a time-dependent explosion mechanism. This delivery system is particularly suitable for delivering viral protease inhibitors to the colon.
Claims14
A drug delivery system comprising:
- a) a core containing a therapeutically effective amount of a biologically-active compound and a swelling agent said swelling agent being present in an amount of from about 5 to about 50% w/w of the core;
- b) a semi-permeable polymer membrane encasing the core which allows water influx but prevents outward diffusion of the biologically active compound, said membrane including a plasticizer, which plasticizer is present in an amount of from about 10 to about 30% w/w of the membrane, wherein the membrane has a percent elongation of from about 2 to about 3.5%;
- and
- c) an outer enteric coating encasing the membrane which coating dissolves at or above about pH 5.5.
1 more element
Dependencies are inferred from the claim text.