Immune response modifier compounds for treatment of TH2 mediated and related diseases
Assignee3M Innovative Properties Company
InventorsMark A. Tomai, David M. Hammerbeck, Karl F. Swingle
Life of this patent
Estimating the term…
Abstract
Immune response modifier compounds--imidazoquinoline amines, imidazopyridine amines, 6,7-fused cycloalkylimidazopyridine amines, and 1,2-bridged imidazoquinoline amines--are useful for the treatment of TH2 mediated diseases by administering a therapeutically effective amount of such compounds in order to inhibit TH2 immune response, suppress IL-4/IL-5 cytokine induction and eosinophilia, as well as enhance TH1 immune response.
Claims12
A method of treating a non-viral and non-tumor, TH2 cell mediated disease comprising administering an immune response modifier compound selected from the group consisting of imidazoquinoline amines, imidazopyridine amines, 6,7-fused cycloalkylimidazopyridine amines, and 1,2-bridged imidazoquinoline amines in an amount effective to inhibit TH2 cell mediated immune response, with the proviso that said disease is other than eczema.
Dependencies are inferred from the claim text.