Blood-compatible material of a supramolecular structure
AssigneeJapan Advanced Institute of Science and Technology, Hokuriku
InventorsNobuhiko Yui, Minoru Terano, Hideharu Mori
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Abstract
A platelet metabolism suppressing blood compatible material has a supramolecular structure containing a plurality of cyclic compounds and a hydrophilic straight-chain polymer threading into cavities of the cyclic compounds. Both terminals of the polymer are respectively capped with biodegradable groups having bulks sufficient to prevent the dethreading of the cyclic compounds.
Claims22
A method of suppressing blood platelet metabolism, comprising contacting blood with a blood platelet metabolism suppressor having a supramolecular structure which comprises:
- a plurality of cyclic compounds having cavities, and
- a hydrophilic straight-chain polymer threading into the cavities of said cyclic compounds, wherein the terminals of said polymer are capped with biodegradable groups having sufficient bulk to prevent the dethreading of said cyclic compounds from the chain of said polymer.
A method of suppressing blood platelet metabolism, comprising contacting blood with a blood platelet metabolism suppressor having a supramolecular structure which consists of:
- one or more cyclodextrins selected from the group consisting of .alpha.-cyclodextrin, .beta.-cyclodextrin, .gamma.-cyclodextrin, hydroxypropylated .alpha.-cyclodextrin, hydroxypropylated .beta.-cyclodextrin, and hydroxypropoylated .gamma.-cyclodextrin, and
- a hydrophilic straight-chain polymer threading into the cavities of said one or more cyclodextrins, wherein the terminals of said polymer are capped with biodegradable groups having sufficient bulk to prevent the dethreading of said one or more cyclodextrins from the chain of said polymer.
Dependencies are inferred from the claim text.