Compositions for prevention of inflammation and adhesion formation uses thereof
AssigneePoly-Med, Inc.
InventorsShalaby W. Shalaby, Julie Miller Hasenwinkel
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Abstract
Pharmaceutical compositions comprising hyaluronic acid, non-steroidal inflammatory drugs, and at least one organic salt of at least one divalent metal, and methods of using these compositions for the inhibition of inflammation and adhesion formation are described. Preferred organic salts of divalent metals include magnesium acetate, zinc acetate, calcium gluconate, and ferrous gluconate. A preferred non-steroidal anti-inflammatory drug is cyclosporin A.
Claims20
A therapeutic composition for use in inhibiting tissue inflammation and adhesion formation in a mammal, said composition comprising hyaluronic acid, a non-steroidal anti-inflammatory agent, and at least one organic salt of at least one divalent metal selected from the group consisting of magnesium actate, zinc acetate, calcium gluconate and ferrous gluconate.
A therapeutic composition for use in inhibiting tissue inflammation and adhesion formation in a mammal, said composition comprising hyaluronic acid, cyclosporin A and at least one organic salt of at least one divalent metal selected from the group consisting of magnesium acetate, zinc acetate, calcium gluconate and ferrous gluconate.
A method of inhibiting or mediating tissue inflammation in mammal tissue, said method comprising administering to said mammal a therapeutic composition comprising hyaluronic acid, a non-steroidal anti-inflammatory agent, and at least one organic salt of at least one divalent metal in a dosage effective to inhibit or mediate local inflammation and adhesion formation in said tissue, wherein said organic salt of a divalent metal is selected from the group consisting of magnesium acetate, zinc acetate, calcium gluconate and ferrous gluconate.
Dependencies are inferred from the claim text.