Tricyclic compounds, their production and use
AssigneeTakeda Chemical Industries, Ltd.
InventorsShigenori Ohkawa, Osamu Uchikawa, Kohji Fukatsu, Masaomi Miyamoto
Life of this patent
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Abstract
A compound of the formula: ##STR1## wherein R.sup.1 is an optionally substituted hydrocarbon, amino or heterocyclic group; R.sup.2 is H or an optionally substituted hydrocarbon group; R.sup.3 is H or an optionally substituted hydrocarbon or heterocyclic group; X is CHR.sup.4, NR.sup.4, O or S in which R.sup.4 is H or an optionally substituted hydrocarbon group; Y is C, CH or N; ring A is optionally substituted 5- to 7-membered ring; ring B is an optionally substituted benzene ring; and m is 1 to 4, or a salt thereof, a process for producing it, an intermediate for the production and a pharmaceutical composition comprising it are provided.
Claims41
A compound of the formula:
- ##STR74## wherein R.sup.1 represents an optionally substituted hydrocarbon group, an optionally substituted amino group or an optionally substituted heterocyclic group;
- R.sup.2 represents a hydrogen atom or an optionally substituted hydrocarbon group;
- R.sup.3 represents a hydrogen atom, an optionally substituted hydrocarbon group, or an optionally substituted heterocyclic group;
- X represents CHR.sup.4, NR.sup.4, O or S in which R.sup.4 represents a hydrogen atom or an optionally substituted hydrocarbon group;
- Y represents C, CH or N, provided that when X is CH.sub.2, Y is C or CH;
- ......... represents a single bond or a double bond;
- ring A represents an optionally substituted, 5- to 7-membered oxygen-containing heterocyclic ring;
- ring B represents an optionally substituted benzene ring;
- and
- m represents an integer of 1 to 4, or a salt thereof.
A compound of the formula:
- ##STR81## wherein R.sup.3 represents a hydrogen atom, an optionally substituted hydrocarbon group, or an optionally substituted heterocyclic group;
- x represents CHR.sup.4, NR.sup.4, O or S in which R.sup.4 represents a hydrogen atom or an optionally substituted hydrocarbon group;
- ring A represents an optionally substituted, 5- to 7-membered oxygen-containing heterocyclic ring;
- ring B represents an optionally substituted benzene ring;
- and
- m represents an integer of 1 to 4, or a salt thereof.
A compound of the formula:
- ##STR82## wherein X.sup.a represents CHR.sup.4a, NR.sup.4a, O or S in which R.sup.4a represents a hydrogen atom or an optionally substituted hydrocarbon group;
- Y.sup.a represents C, CH or N, provided that when X.sup.a is NH or NCH.sub.3, Y.sup.a is CH or N;
- .... represents a single bond or a double bond;
- R.sup.3 represents a hydrogen atom, an optionally substituted hydrocarbon group, or an optionally substituted heterocyclic group;
- ring A represents an optionally substituted, 5- to 7-membered oxygen-containing heterocyclic ring;
- ring B represents an optionally substituted benzene ring;
- and
- m represents an integer of 1 to 4, or a salt thereof.
Dependencies are inferred from the claim text.