US 6,034,233 AGranted

2'-O-alkylated oligoribonucleotides and phosphorothioate analogs complementary to portions of the HIV genome

AssigneeIsis Pharmaceuticals, Inc.

InventorsDavid Ecker, Timothy A. Vickers

Life of this patent

Estimating the term…

Abstract

Methods of modulating the activity of the TAR element of HIV are provided. Oligonucleotides having 6 to 50 bases and at least one 2'-O alkyl modification and selected sequences are disclosed.

Claims7

Dependent claims

An oligonucleotide having a nucleotide sequence selected from the group consisting of SEQ. ID. No. 1, SEQ. ID. No. 2, SEQ. ID. No. 3, SEQ. ID. No. 5, SEQ. ID. No. 6, SEQ. ID. No. 7, SEQ. ID. No. 8, and SEQ. ID. No. 9 and at least one C.sub.1 to C.sub.9 alkyl or benzyl 2'-O-modification.

Dependencies are inferred from the claim text.

Facts

Application: 07/794,396Filed 19 Nov 1991 · continuation in part
Priority: 4 May 1990
Granted: 7 Mar 2000
Term ends: Not estimatedThe source records don’t support an estimate.

Classification11 codes

A61K 31/70
Medicinal preparations containing organic active ingredients: carbohydrates; Sugars; Derivatives thereof
C07K 14/005
Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof: from viruses
C12N 15/1132
Against viruses: against retroviridae, e.g. HIV
C12N 15/63
Recombinant DNA-technology: introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression

Family

Serial578,929Parent of this continuation-in-part · filed 4 May 1990
PCTUS9102558Parent of this continuation-in-part · filed 15 Apr 1991
US 6,034,233 AThis patent

From the US filing history. Foreign family members aren’t listed.

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