1-Amino-alkylcyclohexane NMDA receptor antagonists

An NMDA-receptor antagonist pharmaceutical composition comprising an effective NMDA-receptor antagonistic amount, or an effective immunomodulatory, antimalarial, anti-Borna virus, or anti-Hepatitis C amount, of a 1-aminoalkylcyclohexane compound selected from the group consisting of those of the formula ##STR13## wherein R* is --(CH.sub.2).sub.n --(CR.sup.6 R.sup.7).sub.m --NR.sup.8 R.sup.9

• wherein n+m=0, 1, or 2
• wherein R.sup.1 through R.sup.7 are independently selected from the group consisting of hydrogen and lower-alkyl (1-6C), at least R.sup.1, R.sup.4, and R.sup.5 being lower-alkyl, and wherein R.sup.8 and R.sup.9 are independently selected from the group consisting of hydrogen and lower-alkyl (1-6C) or together represent lower-alkylene --(CH.sub.2).sub.x -- wherein x is 2 to 5, inclusive, and optical isomers, enantiomers, hydrates, and pharmaceutically-acceptable salts thereof, in combination with one or more pharmaceutically-acceptable diluents, excipients, or carriers.