Antisense inhibition of MAP kinase kinase 6 expression
AssigneeIsis Pharmaceuticals, Inc.
InventorsBrett P. Monia, Lex M. Cowsert
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Abstract
Antisense compounds, compositions and methods are provided for modulating the expression of MAP kinase kinase 6. The compositions comprise antisense compounds, particularly antisense oligonucleotides, targeted to nucleic acids encoding MAP kinase kinase 6. Methods of using these compounds for modulation of MAP kinase kinase 6 expression and for treatment of diseases associated with expression of MAP kinase kinase 6 are provided.
Claims20
An antisense compound 8 to 30 nucleobases in length targeted to a start codon, a 3'-untranslated region, a coding region, a stop codon, or a 5'-untranslated region of human MAP kinase kinase 6, wherein said antisense compound specifically hybridizes with and inhibits the expression of human MAP kinase kinase 6.
An antisense compound up to 30 nucleobases in length comprising at least and 8-nucleobase portion of SEQ ID NO:
- 9, 10, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 27, 29, 30, 31, 32, 33, 34, 35, 38, 39, 40, 41, 43, 44, 45, 46 or 47 which inhibits the expression of human MAP kinase kinase 6.
Dependencies are inferred from the claim text.