Method and device for percutaneous sealing of internal puncture sites

A device for percutaneously sealing an internal puncture site, the puncture being formed in a portion of a blood vessel wall and being accessible through a perforation formed through the skin and subcutaneous tissue of a living being with an elongated guide wire being inserted through the perforation, the puncture, and into the vessel, said device comprising:

• a locating device constructed and arranged to be mounted for longitudinal movement relative to said guide wire towards and away from the puncture site;
• a supply of fluid thrombogenic material which will be capable of promoting clotting when delivered to the puncture site;
• delivery structure having a distal end portion and being constructed and arranged to be mounted for longitudinal movement relative to said guide wire towards and away from the puncture site, said delivery structure having a fluid passageway open to said distal end portion thereof and communicated to said supply of fluid thrombogenic material;
• a tubular puncture site engaging member having a distal end portion, said puncture site engaging member being mounted exteriorly of said delivery structure for longitudinal movement relative to said guide wire towards and away from the puncture site;
• said locating device and said puncture site engaging member being constructed and arranged to be positioned with respect to one another such that said puncture site engaging member and said locating device can be moved together longitudinally along the guide wire towards the puncture site, said locating device being constructed and arranged to transmit a signal to the user indicating that the distal end portion of said puncture site engaging member is engaged with the vessel wall portion in surrounding relation with respect to the puncture;
• said delivery structure being constructed and arranged such that the distal end portion of said delivery structure can be positioned adjacent the puncture site and the fluid thrombogenic material can be delivered from said supply to the puncture site through the fluid passageway of said delivery structure when the distal end portion of said puncture site engaging member is engaged with the vessel wall portion in surrounding relation with respect to the puncture;
• said puncture site engaging member being constructed and arranged such that the distal end portion thereof will surround the fluid thrombogenic material being delivered to the puncture site so as to prevent the material from flowing away from the puncture site when the distal end portion of said puncture site engaging member is engaged with the vessel wall portion in surrounding relation with respect to the puncture, thereby allowing the material to promote clotting and seal the puncture.

A method for percutaneously sealing of an internal puncture site comprising a tissue portion having a puncture formed therethrough, the puncture site being accessible through a perforation formed through the skin and subcutaneous tissue of a living being with an elongated guide wire being inserted through the perforation and into the puncture, said method comprising:

• providing a locating device;
• providing a supply of fluid thrombogenic material which will be capable of promoting clotting when delivered to the puncture site;
• providing delivery structure having a distal end portion, said delivery structure having a fluid passageway open to said distal end portion thereof and communicated to said supply of fluid thrombogenic material;
• providing a puncture site engaging member having a distal end portion, said puncture site engaging member being mounted exteriorly of said delivery structure a nd being positioned with respect to said locating device such that said puncture site engaging member and said locating device can be moved longitudinally together along the guide wire toward the puncture site;
• moving said puncture site engaging member an d said locating device longitudinally along said guide wire towards the puncture site until said locating device transmits a signal to the user indicating that the distal end portion of said puncture site engaging member is engaged with a tissue portion of the puncture site in surrounding relation with respect to th e puncture;
• after said locating device has signaled the user that the distal end portion of said puncture site engaging member is engaged with the tissue portion in surrounding relation with respect to the puncture, delivering the fluid thrombogenic material from said supply to the puncture site through said fluid passageway;
• and
• maintaining the distal end portion of said puncture site engaging member in engagement with the tissue portion as the fluid thrombogenic material is being delivered such that the distal end portion of said puncture site engaging member surrounds the fluid thrombogenic material being delivered to the puncture site so as to prevent the material from flowing away from the puncture site, thereby allowing the material to promote clotting and seal the puncture.

A method for percutaneously sealing of an internal puncture site, the internal puncture site being formed in the wall of a blood vessel and being accessible through a perforation formed through the skin and subcutaneous tissue of a living being with an elongated guide wire being inserted through the perforation, the puncture, and into the vessel, said method comprising:

• providing a locating device;
• providing a supply of fluid thrombogenic material which will be capable of promoting clotting when delivered to the puncture site;
• providing delivery structure having a distal end portion, said delivery structure having a fluid passageway open to said distal end portion thereof and communicated to said supply of fluid thrombogenic material;
• providing a puncture site engaging member having a distal end portion, said puncture site engaging member being mounted exteriorly of said delivery structure and being positioned with respect to said locating device such that said puncture site engaging member and said locating device can be moved longitudinally together along the guide wire toward the puncture site;
• moving said puncture site engaging member and said locating device longitudinally along said guide wire towards the puncture site until said locating device transmits a signal to the user indicating that the distal end portion of said puncture site engaging member is engaged with a vessel wall portion in surrounding relation with respect to the puncture;
• after said locating device has transmitted the signal indicating that the distal end portion of said puncture site engaging member is engaged with the vessel wall portion in surrounding relation with respect to the puncture, delivering the fluid thrombogenic material from said supply to the puncture site through said fluid passageway;
• maintaining the distal end portion of said puncture site engaging member in engagement with the vessel wall portion as the fluid thrombogenic material is being delivered such that the distal end portion of said puncture site engaging member surrounds the fluid thrombogenic material being delivered to the puncture site so as to prevent the material from flowing away from the puncture site, thereby allowing the material to promote clotting and seal the puncture.

A sealing device for percutaneously sealing of an internal puncture site comprising a tissue portion having a puncture formed therethrough, the puncture site being accessible through a perforation formed through the skin and subcutaneous tissue of a living being with an elongated guide wire being inserted though the perforation and into the puncture, said device comprising:

• closure structure constructed and arranged to seal the puncture in response to manual operation when said sealing device is in a proper operating position with respect to the puncture site;
• and
• a locating device having a distal end portion with a distal port and a proximal port spaced apart generally longitudinally and open to the exterior of said distal end portion thereof, said locating device being constructed and arranged to be mounted for longitudinal movement relative to the guide wire towards and away from the puncture site and defining first and second fluid passageways connected to said locating distal port and said proximal port, respectively;
• said distal port and said first fluid passageway being constructed and arranged such that, when the distal port is positioned interiorly of the puncture site, fluid located interiorly of the puncture site will be allowed to flow into said distal port and proximally through said first fluid passageway;
• said proximal port and said second fluid passageway being constructed and arranged such that, when the proximal port is positioned interiorly of the puncture site, the fluid located interiorly of the puncture site will be allowed flow into said proximal port and proximally through said second fluid passageway;
• said locating device being constructed and arranged to be moved longitudinally along the guide wire towards the puncture site, said locating device being constructed and arranged such that only the distal port of the distal and proximal ports will be positioned interiorly of the puncture site when said sealing device has reached the proper operating position thereof with respect to the puncture site so that the presence of fluid flowing proximally within said first fluid passageway and the absence of fluid flowing proximally within said second fluid passageway will indicate that the sealing device is in the proper operating position with respect to the puncture site.

A sealing device for percutaneously sealing of an internal puncture site, the puncture site being formed through the a portion of a blood vessel wall and being accessible through a perforation formed through the skin and subcutaneous tissue of a living being with an elongated guide wire being inserted through the perforation, the puncture, and into the vessel, said device comprising:

• closure structure constructed and arranged to seal the puncture in response to manual operation when said sealing device is in a proper operating position with respect to the puncture site;
• and
• a locating device having a distal end portion with a distal port and a proximal port spaced apart generally longitudinally and open to the exterior of said distal end portion thereof, said locating device being constructed and arranged to be mounted for longitudinal movement relative to the guide wire towards and away from the puncture site and defining first and second fluid passageways connected to said distal port and said proximal port, respectively;
• said distal port and said first fluid passageway being constructed and arranged such that, when the distal port is positioned inside the blood vessel, blood flowing through the blood vessel will be allowed to flow into said distal port and proximally through said first fluid passageway;
• said proximal port and said second fluid passageway being constructed and arranged such that, when the proximal port is positioned inside the blood vessel, blood flowing through the puncture site will be allowed to flow into said proximal port and proximally through said second fluid passageway;
• said locating device being constructed and arranged to be moved longitudinally along the guide wire towards the puncture site, said locating device being constructed and arranged such that only the distal port of the distal and proximal ports will be positioned inside the blood vessel when said sealing device has reached the proper operating position thereof with respect to the puncture site so that the presence of blood flowing proximally within said first fluid passageway and the absence of blood flowing proximally within said second fluid passageway will indicate that the sealing device is in the proper operating position with respect to the puncture site.