Substituted pyridines
AssigneePfizer Inc.
InventorSteven W. Wright
Life of this patent
Estimating the term…
Abstract
The present invention relates to certain compounds of the formula (I), ##STR1## which are useful in the synthesis of certian .beta.-adrenergic receptor agonists. The invention also relates to a process for synthesizing the compounds of formula (I) and to compounds of the formula (II), ##STR2## wherein R.sup.1, R.sup.2 and R.sup.4 are defined herein, which are useful in the synthesis of the compounds of formula (I). The invention also relates to a process for synthesizing a compound of formula (II). The invention further relates to processes for synthesizing compounds of formula (Z*), ##STR3## R.sup.1, R.sup.2 and Y.sup.2* are defined herein.
Claims5
A process for the preparation of a compound of formula (II), ##STR28## comprising, reacting a compound of formula (III), ##STR29## with a vinyl ether of formula (IV), CH.sub.2 .dbd.CHOR.sup.4, in the presence of a palladium compound or a palladium metal catalyst, a phosphine and a base;
- wherein
- X.sup.1 is bromo,
- R.sup.1 is selected from the group consisting of --NR.sup.3 --CO--(C.sub.1 -C.sub.10)alkyl, --NR.sup.3 --CO.sub.2 --(C.sub.1 -C.sub.10)alkyl, --NR.sup.3 --CO.sub.2 --(CH.sub.2).sub.a -(optionally substituted phenyl), --NR.sup.3 --CO--(CH.sub.2).sub.a -(optionally substituted phenyl), --NR.sup.3 --SO.sub.2 --(C.sub.1 -C.sub.10)alkyl, --NR.sup.3 --SO.sub.2 --(CH.sub.2).sub.a -(optionally substituted phenyl) and --NR.sup.3 --CO--(C.sub.1 -C.sub.4)perfluoroalkyl;
- R.sup.2 is selected from the group consisting of hydrogen, amino, nitro, (C.sub.1 -C.sub.8)alkyl-amino, fluoro, CF.sub.3, (C.sub.1 -C.sub.4)alkyl, (C.sub.1 -C.sub.4)alkoxy, --NR.sup.3 --CO--(C.sub.1 -C.sub.10)alkyl, --NR.sup.3 --CO.sub.2 --(C.sub.1 -C.sub.10)alkyl, --NR.sup.3 --CO.sub.2 --(CH.sub.2).sub.a -(optionally substituted phenyl), --NR.sup.3 --CO--(CH.sub.2).sub.a -(optionally substituted phenyl), --NR.sup.3 --SO.sub.2 --(C.sub.1 -C.sub.10)alkyl, --NR.sup.3 --SO.sub.2 --(CH.sub.2).sub.a -(optionally substituted phenyl) and --NR.sup.3 --CO--(C.sub.1 -C.sub.4)perfluoroalkyl;
- where a for each occurrence is independently 0, 1, 2, 3 or 4;
- R.sup.3 for each occurrence is independently selected from the group consisting of hydrogen and (C.sub.1 -C.sub.6) alkyl;
- the optionally substituted phenyl group is optionally substituted with one, two or three substituents, each substituent is independently selected from the group consisting of hydroxy, fluoro, chloro, iodo, bromo, CF.sub.3, sulfonamide, (C.sub.1 -C.sub.4)alkyl, (C.sub.1 -C.sub.4)alkoxy, carboxy, hydroxyalkyl, (C.sub.1 -C.sub.4)alkoxycarbonyl, (C.sub.1 -C.sub.4)thioalkyl, sulfonyl, sulfinyl and amino;
- and
- R.sup.4 is (C.sub.1 -C.sub.6)alkyl.
Dependencies are inferred from the claim text.