Salts of metformin and method
AssigneeBristol-Myers Squibb Company
InventorsPeter Timmins, William J. Winter, Sushil K. Srivastava, Alison E. Bretnall, Chenkou Wei, Gerald L. Powers
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Abstract
Novel salts of the antidiabetic agent metformin acre provided which are metformin salts of dibasic acids (2:1 molar ratio), preferably metformin (2:1) fumarate and metformin (2:1) succinate, which may be employed alone or in combination with another antihyperglycemic agent such as glyburide, for treating diabetes. A method for treating diabetes employing the novel metformin salt by itself or in combination with another antidiabetic agent is also provided.
Claims24
A metformin salt of a dibasic acid in a molar ratio of 2 moles metformin to 1 mole dibasic acid, having a solubility in water (mg/ml) at ambient temperature of less than about 150 mg/ml. which is metformin (2:1) fumarate or metformin (2:1) succinate.
A combination of a metformin salt of a dibasic acid in a molar ratio of 2 moles metformin to 1 mole dibasic acid, which metformin salt is the metformin (2:1) fumarate or the metformin (2:1) succinate, and another antihyperglycemic agent.
A metformin salt of a dibasic acid in a molar ratio of 2 moles metformin to 1 mole dibasic acid, which is metformin (2:1) fumarate.
A metformin salt of a dibasic acid in a molar ratio of 2 moles metformin to 1 mole dibasic acid, which is metformin (2:1) succinate.
A pharmaceutical composition comprising metformin (2:1) fumarate and a pharmaceutically acceptable carrier therefor.
A combination comprising metformin (2:1) fumarate and glyburide.
A combination comprising metformin (2:1) fumarate and glipizide.
A pharmaceutical composition comprising metformin (2:1) fumarate and glipizide, and a pharmaceutically acceptable carrier therefor.
Dependencies are inferred from the claim text.